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Ethyl 2,2-bis(4-methylphenylsulfonamido)acetate to aromatic alpha-amino acids: ...

This paper reports the development of a novel methodology for the catalytic synthesis of aromatic alpha-amino acids, which involves the addition of aryl-organoboron reagents to alpha,alpha-ditosylamino esters derived from ethyl glyoxylate, using transition metal catalysts, like Rh and Pd. A library of alpha-amino esters (12 with Pd and 8 with Rh), was synthesized with moderate to excellent yields. A highest ena...

Acetate-induced apoptosis in colorectal carcinoma cells involves lysosomal memb...

Colorectal carcinoma (CRC) is one of the most common causes of cancer-related mortality. Short-chain fatty acids secreted by dietary propionibacteria from the intestine, such as acetate, induce apoptosis in CRC cells and may therefore be relevant in CRC prevention and therapy. We previously reported that acetic acid-induced apoptosis in Saccharomyces cerevisiae cells involves partial vacuole permeabilization an...

Vacuole-mitochondrial crosstalk during apoptosis induced by acetic acid in yeast

Vacuole-mitochondrial crosstalk during apoptosis in yeast: a model for understa...

The yeast apoptosis field emerged with the finding that key components of the apoptotic machinery are conserved in these simple eukaryotes. Thus it became possible to exploit these genetically tractable organisms to improve our understanding of the intricate mechanisms of cell death in higher eukaryotes and of severe human diseases associated with apoptosis dysfunctions. Early on, it was recognized that a mitoc...

What yeast can tell us about how cells commit suicide?

Multicellular organisms developed a complex system to balance cell proliferation and cell death in order to guarantee correct embryonic development and tissue homeostasis. Failure of cells to undergo programmed cell death (PCD) can potentially lead to severe diseases, including neural degeneration, autoimmunity and cancer. Identifying the molecules involved in PCD and understanding the regulation of the process...

Neurotological symptoms and academic performance of university students

OBJECTIVE: To compare the academic performance of university students with or without neurotological symptoms. METHOD: 100 students enrolled in the Biomedical Sciences Graduate School - Medical Modality of UNIFESP-EPM in 2007 and answered a neurotological screening questionnaire. RESULTS: The symptoms presented once, sometimes, many times or always, in a decreasing order of prevalence, were headache (74.0%), di...

Study the response to acetate in colorectal carcinoma cells harbouring differen...

O carcinoma colorectal é o terceiro tipo de cancro mais comum no mundo, estimando-se que existam mais de um milhão de novos casos por ano e aproximadamente metade dos casos resultam em morte, sendo uma das causas mais comuns de morte por cancro no mundo. Neste contexto, torna-se importante a descoberta de novas abordagens terapêuticas para este tipo de carcinomas. Existem dois oncogenes principais implicados no...

Neurocysticercosis and microscopic hippocampal dysplasia in a patient with refr...

Epidemiologic studies suggest that neurocysticercosis (NC) is the main cause of symptomatic epilepsy in developing countries. The association between NC and mesial temporal lobe epilepsy (MTLE) has been reported by several authors. Recent data have shown that the presence of NC does not influence the clinical and pathological profile in MTLE patients and suggest that not all cysticercotic lesions are inevitably...

Partilhando formação, prática e dilemas: uma contribuição ao desenvolvimento do...

O presente trabalho objetivou analisar momentos que caracterizam a prática, a formação e os dilemas cotidianos do profissional práticoreflexivo, buscando compreender suas crenças. Foram realizados 23 encontros entre seis professoras e uma psicóloga. As falas transcritas, divididas em 11 categorias, foram submetidas a entrevistas recorrentes. Os resultados indicaram a necessidade de vincular, na formação e no co...

Embalagens plásticas para pêssegos ‘flordaprince’ refrigerados

Pêssegos cv. Flordaprince foram armazenados a 1 ± 1oC e 85-90% de umidade relativa, em diferentes tipos de embalagens plásticas, por períodos de 14 e 28 dias. Os tratamentos envolveram o uso de filme de PVC, polietileno de alta densidade, polietileno de baixa densidade e o controle (sem embalagem). As frutas desta cultivar puderam ser armazenadas por 14 dias, enquanto que aos 28 dias houve alta incidência de in...