BorArAm - Catalytic Asymmetric Arylating Cyclizations: A New Route to Chiral Bi...

• Autor(es): Mendes, Paulo J. ; Viana, H. ; Marques, C. S. ; Burke, Anthony J.
• Data: 2013
• Identificador Persistente: http://hdl.handle.net/10174/8856
• Origem: Repositório Científico da Universidade de Évora
• Assunto(s): Asymmetric Catalysis; Bicyclic Amines
• Tipo de Documento: Palestra
• Idioma: Inglês

Descrição

Nowadays neurodegenerative diseases such as Alzheimer’s disease and Parkinson disease represent a worldwide health threat. Rasagiline is one well-known medication for the treatment of Parkinson's disease, but more and cheaper alternatives are required.1 For this reason, our group is currently investigating a new catalytic asymmetric arylating2 cyclization route - borylation-arylation-amination (BorArAm) (Scheme 1) giving useful potential lead compounds based on the rasagiline core structure for treating these diseases. Our results will be discussed in this communication.