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BoImAr: Borylation(Catalytic)-Imination-Arylation(Catalytic) - A New Synthetic ...

Although dramatic progress has been made in understanding the pathogenesis of neurodegenerative conditions of the aged population such as Alzheimer's disease, Parkinson's disease and Fronto-Temporal dementia, to date most of these diseases are incurable. Because of the aging population, these disorders pose a serious challenge to the health care system. Loss of synapses is probably the common neuropathological ...

BorArAm - Catalytic Asymmetric Arylating Cyclizations: A New Route to Chiral Bi...

Nowadays neurodegenerative diseases such as Alzheimer’s disease and Parkinson disease represent a worldwide health threat. Rasagiline is one well-known medication for the treatment of Parkinson's disease, but more and cheaper alternatives are required.1 For this reason, our group is currently investigating a new catalytic asymmetric arylating2 cyclization route - borylation-arylation-amination (BorArAm) (Scheme...

Avaliação e Caraterização da Ação Inibitória de Iminociclitóis na Atividade α-G...

A diabetes, em particular a diabetes mellitus tipo 2, constitui um distúrbio metabólico que se carateriza por glicemias aumentadas resultantes de diminuição da libertação e/ou ação da insulina. Os inibidores das α-glucosidases surgem como agentes de elevado interesse terapêutico uma vez que podem contribuir para a diminuição da absorção intestinal de glicose e, consequentemente, para um desagravamento da hiperg...

Walphos and (R,R)-duphos-IPR ligands in the PD(0) catalysed asymmetric allylic ...