BorArAm - Catalytic Asymmetric Arylating Cyclizations: A New Route to Chiral Bi...

• Author(s): Mendes, Paulo J. ; Viana, H. ; Marques, C. S. ; Burke, Anthony J.
• Date: 2013
• Persistent ID: http://hdl.handle.net/10174/8856
• Origin: Repositório Científico da Universidade de Évora
• Subject(s): Asymmetric Catalysis; Bicyclic Amines
• Document Type: Lecture
• Language: English

Description

Nowadays neurodegenerative diseases such as Alzheimer’s disease and Parkinson disease represent a worldwide health threat. Rasagiline is one well-known medication for the treatment of Parkinson's disease, but more and cheaper alternatives are required.1 For this reason, our group is currently investigating a new catalytic asymmetric arylating2 cyclization route - borylation-arylation-amination (BorArAm) (Scheme 1) giving useful potential lead compounds based on the rasagiline core structure for treating these diseases. Our results will be discussed in this communication.