A whole genome screen for association with multiple sclerosis in Portuguese pat...

• Author(s): Santos, M ; Pinto-Basto, J ; Rio, ME ; Sá, MJ ; Valença, A ; Sá, A ; Dinis, J ; Figueiredo, J ; Bigotte de Almeida, L ; Coelho, I ; Sawcer, S ; Setakis, E ; Compston, A ; Sequeiros, J ; Maciel, P
• Date: 2003
• Origin: Repositório Comum
• Subject(s): Predisposição Genética para Doença; Portugal; Esclerose Múltipla; Testes Genéticos
• Document Type: Article
• Language: English

Description

Multiple sclerosis (MS) is common in Europe affecting up to 1:500 people. In an effort to identify genes influencing susceptibility to the disease, we have performed a population-based whole genome screen for association. In this study, 6000 microsatellite markers were typed in separately pooled DNA samples from MS patients (n=188) and matched controls (n=188). Interpretable data was obtained from 4661 of these markers. Refining analysis of the most promising markers identified 10 showing potential evidence for association.