Methodologies for the separation of chiral drugs by liquid chromatography: from...

• Autor(es): Ribeiro, António E. ; Rodrigues, A.E. ; Pais, L.S.
• Data: 2012
• Identificador Persistente: http://hdl.handle.net/10198/9153
• Origem: Biblioteca Digital do IPB
• Assunto(s): Chiral separation; Simulated moving bed
• Tipo de Documento: Documento de conferência
• Idioma: Inglês

Descrição

The main goal of the present work is to clear demonstrate that the selection of the proper solvent composition is a key step for both analytical and preparative separations. A complete methodology developed in the last years inside the LSRE group will be described. Three real optimization case-studies will be presented: two non-steroidal anti-inflammatory drugs (the separation of ketoprofen and flurbiprofen enantiomers) and one antihypertensive drug (the separation of nadolol stereoisomers).