Chiral separation of nadolol stereoisomers by liquid chromatography : screening...

• Author(s): Ribeiro, António E. ; Pais, L.S. ; Rodrigues, A.E.
• Date: 2012
• Persistent ID: http://hdl.handle.net/10198/9145
• Origin: Biblioteca Digital do IPB
• Subject(s): Nadolol; Chiral separation; Mobile phase composition; Simulated moving red
• Document Type: Conference Object
• Language: English

Description

This work describes a systematic approach to rapid development of simulated moving bed (SMB) chiral chromatographic separations. The presented methodology involves several pulse experiments using a single-column to screen the best mobile phase composition using a Chiralpak AD stationary phase and equilibrium adsorption data used to specify the initial flow rates of the SMB operation.