Screening of antimicrobial activity of diarylamines in the 2,3,5-trimethylbenzo...

• Author(s): Ferreira, Isabel C.F.R. ; Calhelha, Ricardo C. ; Estevinho, Leticia M. ; Queiroz, Maria João R.P.
• Date: 2004
• Persistent ID: http://hdl.handle.net/10198/821
• Origin: Biblioteca Digital do IPB
• Subject(s): Diarylamines; Antimicrobial activity; SAR; Benzothiophenes
• Document Type: Article
• Language: English

Description

Gram positive (Bacillus cereus, B. subtilis), Gram negative (Pseudomonas aeruginosa, Escherichia coli) bacteria, and Candida albicans as a representative of fungi were used for screening the in vitro antimicrobial activity of diarylamines in the 2,3,5-trimethylbenzo[ b]thiophene series bearing different substituents, synthesized by us using the palladium-catalyzed C–N coupling methodology. The minimal inhibitory concentration (MIC) and structure–activity relationships (SARs) were evaluated.