Preparative separation of profen enantiomers by liquid chromatography

• Author(s): Ribeiro, António E. ; Graça, Nuno S. ; Pais, L.S. ; Rodrigues, A.E.
• Date: 2007
• Persistent ID: http://hdl.handle.net/10198/1160
• Origin: Biblioteca Digital do IPB
• Subject(s): Profen enantiomers; Chiral separation; Preparative chromatography; Mobile phase composition
• Document Type: Conference Object
• Language: English

Description

Profens. or 2•aryfpropionic acids. are an important sub-class of the frequently prescribed non-steraidal anti-inflammatory drugs (NSAIDs). Some of the main primary indications for NSAIDs therapy include rheumatoid arthritis, osteoarthritis, acute gouty arthritis, dysmenorrhea and acute pain. Ketoprofen (R.S)-2-(3-benzoylphenylpropionic acid) and Flurbiprofen (R,S)-2-(2-fluoro-4- -biphenylprapionic acid) are examples of NSAIDs, both marketed as racemic mixtures.