Chiral separation of profen enantiomers by preparative liquid chromatography

• Author(s): Ribeiro, António E. ; Graça, Nuno S. ; Pais, L.S. ; Rodrigues, A.E.
• Date: 2008
• Persistent ID: http://hdl.handle.net/10198/1159
• Origin: Biblioteca Digital do IPB
• Subject(s): Profen enantiomers; Chiral separation; Preparative chromatography; Mobile phase composition
• Document Type: Conference Object
• Language: English

Description

In this work, experimental results obtained for the ketoprofen and flurbiprofen enantiomers systems will be shown, including solubility and adsorption measurements, and pulse and breakthrough experiments. Additionally, simulation results, based on the experimental adsorption isotherms measurements, will be presented to compare the performance of fixed-bed and SMB processes. The experimental and simulation results show two different situations. For the separation of ketoprofen enantiomers, pure ethanol is clearly a better mobile phase than the usual high alkane content mobile phases. On the other hand, for the separation of flurbiprofen enantiomers, a 10%ethanol/90%n-hexane is proposed. The results obtained show that an individual study must be carried out for each enantioseparation system, since different profen drugs can show different behaviours.