Patterns of genetic variation in populations of infectious agents

• Author(s): Gordo, I. ; Campos, P.R.A.
• Date: 2007
• Persistent ID: http://hdl.handle.net/10400.7/40
• Origin: ARCA - Access to Research and Communication Annals
• Subject(s): Genetic Variation; Genetics, Population; Host-Parasite Interactions/genetics; Infection/microbiology/virology; Models, Genetic; Humans
• Document Type: Article
• Language: English

Description

The analysis of genetic variation in populations of infectious agents may help us understand their epidemiology and evolution. Here we study a model for assessing the levels and patterns of genetic diversity in populations of infectious agents. The population is structured into many small subpopulations, which correspond to their hosts, that are connected according to a specific type of contact network. We considered different types of networks, including fully connected networks and scale free networks, which have been considered as a model that captures some properties of real contact networks. Infectious agents transmit between hosts, through migration, where they grow and mutate until elimination by the host immune system