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Mutation, Selection and Genetic Interactions in Bacteria
Gordo, I.; Sousa, A.Mutation is the ultimate source of genetic variation. The rate at whichnew mutations typically occurs, their effects on fitness and the strength and type of genetic interactions between different mutations are key for understanding the evolution of any population. Estimates of these parameters in organisms such as bacteria will have a profound impact on our understanding of their biology, diversity, rate of spe...
Rate and effects of spontaneous mutations that affect fitness in mutator Escher...
Gordo, I.; Perfeito, L.; Trindade, S.Knowledge of the mutational parameters that affect the evolution of organisms is of key importance in understanding the evolution of several characteristics of many natural populations, including recombination and mutation rates. In this study, we estimated the rate and mean effect of spontaneous mutations that affect fitness in a mutator strain of Escherichia coli and review some of the estimation methods asso...
Cognitive and motivational requirements for the emergence of cooperation in a r...
Viana, DS; Gordo, I; Sucena, E; Moita, MABackground: Game theory and the Prisoner's Dilemma (PD) game in particular, which captures the paradox of cooperative interactions that lead to benefits but entail costs to the interacting individuals, have constituted a powerful tool in the study of the mechanisms of reciprocity. However, in non-human animals most tests of reciprocity in PD games have resulted in sustained defection strategies. As a consequenc...
Cognitive and motivational requirements for the emergence of cooperation in a r...
Viana, DS; Gordo, I; Sucena, E; Moita, MAPGame theory and the Prisoner's Dilemma (PD) game in particular, which captures the paradox of cooperative interactions that lead to benefits but entail costs to the interacting individuals, have constituted a powerful tool in the study of the mechanisms of reciprocity. However, in non-human animals most tests of reciprocity in PD games have resulted in sustained defection strategies. As a consequence, it has be...
Cognitive and Motivational Requirements for the Emergence of Cooperation in a R...
Viana, DS.; Gordo, I.; Sucena, E.; Moita, M.A.P.Background: Game theory and the Prisoner's Dilemma (PD) game in particular, which captures the paradox of cooperative interactions that lead to benefits but entail costs to the interacting individuals, have constituted a powerful tool in the study of the mechanisms of reciprocity. However, in non-human animals most tests of reciprocity in PD games have resulted in sustained defection strategies. As a consequenc...
Genetic recombination and molecular evolution
Gordo, I.; Charlesworth, B.; Kaiser, V.B.; Betancourt, A.J.Reduced rates of genetic recombination are often associated with reduced genetic variability and levels of adaptation. Several different evolutionary processes, collectively known as Hill–Robertson (HR) effects, have been proposed as causes of these correlates of recombination. Here, we use DNA sequence polymorphism and divergence data from the noncrossing over dot chromosome of Drosophila to discriminate betwe...
Positive epistasis drives the acquisition of multidrug resistance
Trindade, S.; Sousa, A.; Xavier, K.B.; Dionísio, F.; Ferreira, M.G.; Gordo, I.The evolution of multiple antibiotic resistance is an increasing global problem. Resistance mutations are known to impair fitness, and the evolution of resistance to multiple drugs depends both on their costs individually and on how they interact--epistasis. Information on the level of epistasis between antibiotic resistance mutations is of key importance to understanding epistasis amongst deleterious alleles, ...
Genetic diversity in the SIR model of pathogen evolution
Gordo, I.; Gomes, M.G.M.; Reis, D.G.; Campos, P.R.A.We introduce a model for assessing the levels and patterns of genetic diversity in pathogen populations, whose epidemiology follows a susceptible-infected-recovered model (SIR). We model the population of pathogens as a metapopulation composed of subpopulations (infected hosts), where pathogens replicate and mutate. Hosts transmit pathogens to uninfected hosts. We show that the level of pathogen variation is we...
Positive Epistasis Drives the Acquisition of Multidrug Resistance
Trindade, S.; Sousa, A.; Xavier, KB.; Dionisio, F.; Ferreira, MG.; Gordo, I.The evolution of multiple antibiotic resistance is an increasing global problem. Resistance mutations are known to impair fitness, and the evolution of resistance to multiple drugs depends both on their costs individually and on how they interact-epistasis. Information on the level of epistasis between antibiotic resistance mutations is of key importance to understanding epistasis amongst deleterious alleles, a...
Positive Epistasis Drives the Acquisition of Multidrug Resistance
Trindade, S.; Sousa, A.; Xavier, KB.; Dionisio, F.; Ferreira, MG.; Gordo, I.The evolution of multiple antibiotic resistance is an increasing global problem. Resistance mutations are known to impair fitness, and the evolution of resistance to multiple drugs depends both on their costs individually and on how they interact-epistasis. Information on the level of epistasis between antibiotic resistance mutations is of key importance to understanding epistasis amongst deleterious alleles, a...
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