Encontrados 2 documentos, a visualizar página 1 de 1
Treatment of acute promyelocytic leukemia with trans-retinoic acid. Experience ...
De Lacerda, J F; Unidade de Hematologia, Universidad de Lisboa, Hospital de Santa Maria, Faculdade de Medicina de Lisboa.; Do Carmo, J A; De Moura, M CAcute promyelocytic leukemia (APL) is a rare subtype of acute myelogenous leukemia that is usually associated with a fatal hemorrhagic diathesis. All trans-retinoic acid (ATRA) is an active metabolite of vitamin A that differentiates the malignant cell clone, corrects the coagulopathy, and induces complete remission in the vast majority of patients with APL. Between June 1992 and September 1993, 8 patients with...
Acute promyelocytic leukemia. The therapeutic advances.
de Lacerda, J F; Unidade de Hematologia, Hospital de Santa Maria, Faculdade de Medicina de Lisboa.; do Carmo, J A; de Lacerda, J MAcute promyelocytic leukemia (APL) is a rare subtype of acute myelogenous leukemia. It is frequently associated with a life-threatening hemorrhagic diathesis, often aggravated by induction cytotoxic chemotherapy. Patients with APL have bone marrow infiltration by abnormal promyelocytes, usually with prominent cytoplasmic granulation. These patients have a unique cytogenetic abnormality, a balanced reciprocal tr...
| Financiadores do RCAAP | |||||||
|
|
|
|
|
|
||