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Acute promyelocytic leukemia. The therapeutic advances.
de Lacerda, J F; Unidade de Hematologia, Hospital de Santa Maria, Faculdade de Medicina de Lisboa.; do Carmo, J A; de Lacerda, J MAcute promyelocytic leukemia (APL) is a rare subtype of acute myelogenous leukemia. It is frequently associated with a life-threatening hemorrhagic diathesis, often aggravated by induction cytotoxic chemotherapy. Patients with APL have bone marrow infiltration by abnormal promyelocytes, usually with prominent cytoplasmic granulation. These patients have a unique cytogenetic abnormality, a balanced reciprocal tr...
Data: 1970
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Origem: Acta Médica Portuguesa
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