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Protein kinase WNK2 as a tumour suppressor gene in malignant gliomas
Moniz, S.; Martinho, O.; Reis, R.M.; Jordan, P.Malignant glioblastomas are the most common and lethal adult brain tumours, with patients dying within two years from diagnosis. Little is known about the molecular mechanisms underlying the formation and/or development of these tumours, which present a very invasive phenotype within the brain and are genetically heterogeneous and highly resistant to both chemo- and radio-therapies. Recently, the promoter regio...
Protein kinase WNK2 regulates cell migration in malignant gliomas
Moniz, S.; Martinho, O.; Reis, R.M.; Jordan, P.Malignant glioblastomas are the most common and lethal adult brain tumours, with patients dying within two years from diagnosis. Little is known about the molecular mechanisms underlying the formation and/or development of these tumours, which present a very invasive phenotype within the brain and are genetically heterogeneous and highly resistant to both chemo- and radio-therapies. Recently, the promoter regio...
Um novo mecanismo molecular para a regulação do transportador de glicose GLUT1
Mendes, A.I.; Matos, P.; Moniz, S.; Jordan, P.Prémio de Investigação Básica ; One mechanism by which cells regulate the uptake of glucose is the number of glucose transporter proteins (GLUT) present at the plasma membrane. In insulin-responsive cells types, GLUT4 is released from intracellular storage vesicles through inactivation of the Rab GTPase activating protein TBC1D4, also known as AS160. Using protein biochemical techniques we analysed complex for...
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