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The metabolic profile of mitoxantrone and its relation with mitoxantrone-induce...
Rossato, Luciana Grazziotin; Costa, Vera Marisa; de Pinho, Paula Guedes; Arbo, Marcelo Dutra; de Freitas, Vitor; Vilain, Laure; Bastos, Maria de LourdesMitoxantrone (MTX) is an antitumor agent that causes cardiotoxicity in 18 % patients. The metabolic profile of MTX was assessed after incubation of 100 lM MTX with hepatic S9 fraction isolated from rats. The presence of MTX and its metabolites was also assessed in vivo through the analysis of liver and heart extracts of MTX-treated rats. The cytotoxic effects of MTX and MTX metabolites were evaluated in the H9c...
Data: 2013
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Origem: Estudo Geral - Universidade de Coimbra
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