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Evaluation of the potential of polyhydroxybutyrate-co-hydroxyvalerate bi-layere...

Zonari, A. A. C.; Cerqueira, M. T.; Novikoff, S.; Goes, A. M.; Marques, A. P.; Correlo, V. M.; Reis, R. L.

Polyhydroxybutyrate-co-hydroxyvalerate (PHB-HV) is natural-based polyester produced by microorganisms under unbalanced growth con- ditions. This polymer is known for its biocompatibility and biodegrad- ability and has been explored for tissue engineering approaches. The aim of this work was to create a bi-layered construct, based on PHB- HV, for skin tissue replacement. The PHB-HV bi-layered scaffold was produc...


Endothelial differentiation of human stem cells seeded onto electrospun polyhyd...

Zonari, A. A. C.; Novikoff, S.; Electo, N. R. P.; Breyner, N. M.; Gomes, D. A.; Martins, A.; Neves, N. M.; Reis, R. L.; Goes, A. M.

Tissue engineering is based on the association of cultured cells with structural matrices and the incorporation of signaling molecules for inducing tissue regeneration. Despite its enormous potential, tissue engineering faces a major challenge concerning the maintenance of cell viability after the implantation of the constructs. The lack of a functional vasculature within the implant compromises the delivery of...


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Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia