Encontrados 4 documentos, a visualizar página 1 de 1
Insulin and Insulin-Sensitizing Drugs in Neurodegeneration: Mitochondria as The...
Cardoso, Susana; Santos, Renato; Correia, Sonia; Carvalho, Cristina; Zhu, Xiongwei; Lee, Hyoung-Gon; Casadesu, Gemma; Smith, Mark A.; Perry, GeorgeInsulin, besides its glucose lowering effects, is involved in the modulation of lifespan, aging and memory and learning processes. As the population ages, neurodegenerative disorders become epidemic and a connection between insulin signaling dysregulation, cognitive decline and dementia has been established. Mitochondria are intracellular organelles that despite playing a critical role in cellular metabolism ar...
Iron: The Redox-active Center of Oxidative Stress in Alzheimer Disease
Castellani, Rudy; Moreira, Paula; Liu, Gang; Dobson, Jon; Perry, George; Smith, Mark; Zhu, XiongweiAbstract Although iron is essential in maintaining the function of the central nervous system, it is a potent source of reactive oxygen species. Excessive iron accumulation occurs in many neurodegenerative diseases including Alzheimer disease (AD), Parkinson’s disease, and Creutzfeldt-Jakob disease, raising the possibility that oxidative stress is intimately involved in the neurodegenerative process. AD in par...
Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stre...
Moreira, Paula I.; Harris, Peggy L. R.; Zhu, Xiongwei; Santos, Maria S.; Oliveira, Catarina R.; Smith, Mark A.; Perry, GeorgeIn this study, we evaluated the effect of lipoic acid (LA) and N-acetyl cysteine (NAC) on oxidative [4-hydroxy-2-nonenal, N(epsilon)-(carboxymethyl)lysine and heme oxygenase-1] and apoptotic (caspase 9 and Bax) markers in fibroblasts from patients with Alzheimer disease (AD) and age-matched and young controls. AD fibroblasts showed the highest levels of oxidative stress, and the antioxidants, lipoic acid (1 mM)...
Tau phosphorylation in Alzheimer's disease: pathogen or protector?
Lee, Hyoung-gon; Perry, George; Moreira, Paula I.; Garrett, Matthew R.; Liu, Quan; Zhu, Xiongwei; Takeda, Atsushi; Nunomura, Akihiko; Smith, Mark A.During the past decade, hypotheses concerning the pathogenesis of most neurodegenerative diseases have been dominated by the notion that the aggregation of specific proteins and subsequent formation of cytoplasmic and extracellular lesions represent a harbinger of neuronal dysfunction and death. As such, in Alzheimer's disease, phosphorylated tau protein, the major component of neurofibrillary tangles, is consi...
| Financiadores do RCAAP | |||||||
|
|
|
|
|
|
||