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Texture image analysis in differentiating malignant from benign adrenal cortica...
Shirata, Neuza Kasumi; Sredni, S. T.; Castelo, A.; Santanelli, A.; Mendon??a, B.; Montironi, R.; Longatto Filho, Adhemar; Zerbini, M. C. N.OBJECTIVE: To investigate the possible role of chromatin texture parameters, nuclear morphology, DNA ploidy and clinical functional status in discriminating benign from malignant adrenocortical tumors (ACT). PATIENTS AND METHODS: Forty-eight cases of clinically benign (n=40) and clinically malignant (n=8) ACT with a minimum of 5-years' follow-up were evaluated for chromatin texture parameters (run length, stand...
p53 as a prognostic factor in adrenocortical tumors of adults and children
Sredni,S.T.; Zerbini,M.C.N.; Latorre,M.R.; Alves,V.A.F.Mutations of the tumor suppressor gene p53 have been considered to be important determinants in several kinds of human cancer. Accumulation of p53 protein has been reported to correlate with more aggressive clinical behavior in some neoplasms. The role of p53 expression in adrenal cortical tumors (ACT) has not been elucidated but some studies have suggested its correlation with malignant behavior. Our objective...
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