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Genetic susceptibility to aspergillosis in allogeneic stem-cell transplantation
Cunha, Cristina; Rodrigues, Fernando José dos Santos; Zelante, Teresa; Aversa, Franco; Romani, Luigina; Carvalho, AgostinhoInvasive aspergillosis (IA) is a major threat to positive outcomes for allogeneic stem-cell transplantation (allo-SCT) patients. Despite presenting similar degrees of immunosuppression, not all individuals at-risk ultimately develop infection. Therefore, the traditional view of neutropenia as a key risk factor for aspergillosis needs to be accommodated within new conceptual advances on host immunity and its rel...
Non-hematopoietic cells contribute to protective tolerance to Aspergillus fumig...
Luca, Antonella De; Bozza, Silvia; Zelante, Teresa; Zagarella, Silvia; Angelo, Carmen de; Perruccio, Katia; Vacca, Carmine; Carvalho, AgostinhoInnate responses combine with adaptive immunity to generate the most effective form of anti-Aspergillus immune resistance. Whereas the pivotal role of dendritic cells in determining the balance between immunopathology and protective immunity to the fungus is well established, we determined that epithelial cells (ECs) also contributes to this balance. Mechanistically, EC-mediated protection occurred through a To...
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