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Modulation of sarcoplasmic reticulum calcium pump activity by membrane fluidity
Almeida, Leonor M.; Vaz, Winchil L. C.; Zachariasse, Klaas A.; Madeira, Vitor M. C.Intramolecular excimerization of 1,3-di- l-pyrenylpropane [Py(3)Py] was used to assess the fluidity of sarcoplasmic reticulum membranes (SR); on the basis of the spectral data, the probe incorporates completely inside the membrane probably somewhere close to the polar head groups of phospholipid molecules, however not in the very hydrophobic core. The excimerization rate is very sensitive to lipid phase transit...
Fluidity of sarcoplasmic reticulum membranes investigated with dipyrenylpropane...
Almeida, Leonor M.; Vaz, Winchil L. C.; Zachariasse, Klaas A.; Madeira, Vitor M. C.Intramolecular excimer formation with 1,3-di( 1 - pyreny1)propane was used to probe the fluidity of sarcoplasmic reticulum (SR) membranes where the probe could be incorporated (in a probe/lipid molar ratio of 1/2OOO or less) without inducing any detectable damage. The temperature was varied between -1 and 40 'C. The fluidity of the native SR membrane changes from 52 CP at 40 OC to 325 CP at 5 'C. The native SR ...
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