Encontrados 11 documentos, a visualizar página 1 de 2
Ursolic acid induces cell death and modulates autophagy through JNK pathway in ...
Xavier, Cristina P. R.; Lima, Cristóvão F.; Pedro, Dalila Fernanda Neto; Wilson, Jonathan M.; Kristiansen, K.; Wilson, Cristina PereiraColorectal carcinomas (CRCs) with P53 mutations have been shown to be resistant to chemotherapy with 5-fluorouracil (5-FU), the most widely used chemotherapeutic drug for CRC treatment. Autophagy is emerging as a promising therapeutic target for drug-resistant tumors. In the present study, we tested the effects of ursolic acid (UA), a natural triterpenoid, on cell death mechanisms and its effects in combination...
Hypericum androsaemum water extract inhibits proliferation in human colorectal ...
Xavier, Cristina P. R.; Lima, Cristóvão F.; Ferreira, Manuel Fernandes; Wilson, Cristina PereiraMAP kinase and PI3K/Akt signalling pathways are commonly altered in colorectal carcinoma (CRC) leading to tumor growth due to increased cell proliferation and inhibition of apoptosis. Several species of the genus Hypericum are used in Portugal to prepare herbal teas to which digestive tract effects are attributed. In the present study, the antiproliferative and proapoptotic effects of the water extracts of H. a...
Ursolic acid, a dietary phytochemical, decreases KRAS signaling and modulates c...
Xavier, Cristina P. R.; Lima, Cristóvão F.; Pedro, Dalila Fernanda Neto; Wilson, Cristina PereiraPublicado em "BMC Proceedings 2012, 6(Suppl 3)" ; KRAS mutations are frequent in colorectal cancer (CRC) and have the potential to activate proliferation and inhibit cell death through effects on MAPK/ERK and PI3K/Akt signaling pathways. Because diet is one of the most important determinants of CRC incidence and progression, we studied the effects of the dietary triterpenoid ursolic acid (UA) on proliferation ...
Quercetin enhances 5-fluorouracil-induced apoptosis in MSI colorectal cancer ce...
Xavier, Cristina P. R.; Lima, Cristóvão F.; Rohde, Mikkel; Wilson, Cristina PereiraPurpose: Colorectal tumors (CRC) with microsatellite instability (MSI) show resistance to chemotherapy with 5-fluorouracil (5-FU), the most widely used pharmacological drug for CRC treatment. The aims of this study were to test the ability of quercetin (Q) and luteolin (L) to increase sensitivity of MSI CRC cells to 5-FU and characterize the dependence of the effects on cells´ p53 status. Methods: Two MSI huma...
Quercetin enhances apoptosis induced by 5-fluorouracil in colorectal cancer cel...
Xavier, Cristina P. R.; Lima, Cristóvão F.; Wilson, Cristina PereiraColorectal tumors (CRC) with microsatellite instability (MSI) show resistance to chemotherapy with 5-fluorouracil (5-FU), the most widely used pharmacological drug for CRC treatment. The aim of this study was to evaluate the effects on apoptosis induction of co-incubation of the flavonoids, quercetin (Q) or luteolin (L), with 5-FU in two MSI human CRC derived cell lines (CO115 wt for p53 and HCT15 mutated for p...
Quercetin synergistically induces sensitivity to 5-fluorouracil through p53 mod...
Xavier, Cristina P. R.; Lima, Cristóvão F.; Wilson, Cristina PereiraColorectal tumors (CRC) with microsatellite instability (MSI) show resistance to chemotherapy with 5-fluorouracil (5-FU), the most widely used pharmacological drug for CRC treatment. The aims of this study were to identify compounds that increase sensitivity of MSI CRC cells to 5-FU and characterize their dependence on the p53 status of the cells. Two MSI human CRC derived cell lines were used: CO115 wildtype f...
Autophagy triggered by ursolic acid synergistically enhances 5-fluorouracil ind...
Xavier, Cristina P. R.; Lima, Cristóvão F.; Rohde, Mikkel; Wilson, Cristina PereiraColorectal carcinoma (CRC) is a common cause of cancer-related death and tumors with microsatellite instability (MSI) and p53 mutations have been shown to be resistant to chemotherapy with 5-fluorouracil (5-FU). Therefore, it is essential to find compounds that could contribute to treatment efficacy by increasing the sensitivity to 5-FU. HCT15, a MSI human CRC derived cell line that harbours a p53 mutation, was...
Quercetin enhances 5-fluorouracil-induced apoptosis in MSI colorectal cancer ce...
Xavier, Cristina P. R.; Lima, Cristóvão F.; Wilson, Cristina PereiraColorectal tumors (CRC) with microsatellite instability (MSI) show resistance to chemotherapy with 5-fluorouracil (5-FU), the most widely used pharmacological drug for CRC treatment. The aims of this study were to test the ability of quercetin (Q) and luteolin (L) to increase sensitivity of MSI CRC cells to 5-FU and characterize the dependence of the effects on cells´ p53 status. Two MSI human CRC derived cell...
The anticarcinogenic potential of dietary natural compounds on colorectal carci...
Xavier, Cristina P. R.Tese de doutoramento em Ciências (área de conhecimento em Biologia) ; Colorectal cancer (CRC) is the third most prevalent cancer worldwide and the incidence is highly influenced by diet. Epidemiological studies have supported the idea that some dietary food components may influence the risk of CRC through modulation of several biological processes, including proliferation, survival and cell death. The PI3K/Akt...
Salvia fruticosa, salvia officinalis and rosmarinic acid induce apoptosis and i...
Xavier, Cristina P. R.; Lima, Cristóvão F.; Ferreira, Manuel Fernandes; Wilson, Cristina PereiraEpidemiologic studies have shown that nutrition is a key factor in modulating sporadic colorectal carcinoma (CRC) risk. Aromatic plants of the genus Salvia (sage) have been attributed many medicinal properties, which include anticancer activity. In the present study, the antiproliferative and pro-apoptotic effects of water extracts of Salvia fruticosa (SF) and Salvia officinalis (SO) and of their main phenolic ...
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