Encontrados 3 documentos, a visualizar página 1 de 1
Protein kinase C activity blocks neuropeptide Y-mediated inhibition of glutamat...
Silva, Ana P.; Lourenço, Joana; Xapelli, Sara; Ferreira, Raquel; Kristiansen, Heidi; Woldbye, David P. D.; Oliveira, Catarina R.; Malva, João O.The unbalanced excitatory/inhibitory neurotransmitter function in the neuronal network afflicted by seizures is the main biochemical and biophysical hallmark of epilepsy. The aim of this work was to identify changes in the signaling mechanisms associated with neuropeptide Y (NPY)-mediated inhibition of glutamate release that may contribute to hyperexcitability. Using isolated rat hippocampal nerve terminals, we...
Up-regulation of neuropeptide Y levels and modulation of glutamate release thro...
Silva, Ana P.; Xapelli, Sara; Pinheiro, Paulo S.; Ferreira, Raquel; Lourenço, Joana; Cristóvão, Armando; Grouzmann, Eric; Cavadas, CláudiaKainate-induced epilepsy has been shown to be associated with increased levels of neuropeptide Y (NPY) in the rat hippocampus. However, there is no information on how increased levels of this peptide might modulate excitation in kainate-induced epilepsy. In this work, we investigated the modulation of glutamate release by NPY receptors in hippocampal synaptosomes isolated from epileptic rats. In the acute phase...
Modulator effects of interleukin-1beta and tumor necrosis factor-alpha on AMPA-...
Bernardino, Liliana; Xapelli, Sara; Silva, Ana P.; Jakobsen, Birthe; Poulsen, Frantz R.; Oliveira, Catarina R.; Vezzani, Annamaria; Malva, João O.The inflammatory cytokines interleukin-1\u2424 and tumor necrosis factor-\u2423 (TNF-\u2423) have been identified as mediators of several forms of neurodegeneration in the brain. However, they can produce either deleterious or beneficial effects on neuronal function. We investigated the effects of these cytokines on neuronal death caused by exposure of mouse organotypic hippocampal slice cultures to toxic conce...
| Financiadores do RCAAP | |||||||
|
|
|
|
|
|
||