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Neuropeptide Y can rescue neurons from cell death following the application of ...
Xapelli, S.; Silva, A. P.; Ferreira, R.; Malva, J. O.In the present work we investigated the neuroprotective role of neuropeptide Y (NPY) after an excitotoxic insult in rat organotypic hippocampal slice cultures. Exposure of 2 week-old rat hippocampal slice cultures to 12 [mu]M kainate (KA) for 24 h induced neuronal death in dentate gyrus (DG) granular cell layer, CA1 and CA3 pyramidal cell layers, as quantified by cellular propidium iodide (PI) uptake. The activ...
Data: 2007
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Origem: Estudo Geral - Universidade de Coimbra
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