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A DNA enzyme targeting Egr-1 inhibits rat vascular smooth muscle cell prolifera...
Wu,Y.; Han,W.; Liu,G.-N.We have demonstrated that a synthetic DNA enzyme targeting early growth response factor-1 (Egr-1) can inhibit neointimal hyperplasia following vascular injury. However, the detailed mechanism of this inhibition is not known. Thus, the objective of the present study was to further investigate potential inhibitory mechanisms. Catalytic DNA (ED5) and scrambled control DNA enzyme (ED5SCR) were synthesized and trans...
Familial C4B deficiency and immune complex glomerulonephritis
Soto, K; Wu, Y; Ortiz, A; Aparício, S; Yu, CHomozygous complement C4B deficiency is described in a Southern European young female patient with Membranoproliferative Glomerulonephritis (MPGN) type III characterized by renal biopsies with strong complement C4 and IgG deposits. Low C4 levels were independent of clinical evolution or type of immunosuppression and were found in three other family members without renal disease or infections. HLA typing reveale...
SMAD pathway mediation of BDNF and TGFβ2 regulation of proliferation and differ...
Lu, J.; Wu, Y.; Sousa, Nuno; Almeida, O. F. X.Hippocampal granule cells self-renew throughout life, whereas their cerebellar counterparts become post-mitotic during early postnatal development, suggesting that locally acting, tissue-specific factors may regulate the proliferative potential of each cell type. Confirming this, we show that conditioned medium from hippocampal cells (CMHippocampus) stimulates proliferation in cerebellar cultures and, vice vers...
Direct targeting of hippocampal neurons for apoptosis by glucocorticoids is rev...
Crochemore, C.; Lu, J.; Wu, Y.; Liposits, Zs.; Sousa, Nuno; Holsboer, F.; Almeida, O. F. X.Prova tipográfica (In Press) ; An important question arising from previous observations in vivo is whether glucocorticoids can directly influence neuronal survival in the hippocampus. To this end, a primary postnatal hippocampal culture system containing mature neurons and expressing both glucocorticoid (GR) and mineralocorticoid (MR) receptors was developed. Results show that the GR agonist dexamethasone (DEX...
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