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Bone response and mechanical strength of rabbit femoral defects filled with inj...

Link, Dennis P.; Van den Dolder, Juliette; Van den Beucken, Jeroen J.; Wolke, Joop G.; Mikos, Antonios G.; Jansen, John A.

This study focused at the potential of transforming growth factor β1 (TGF-β1) loaded gelatin microparticles to enhance the bone response and mechanical strength of rabbit femoral defects filled with injectable calcium phosphate (CaP)/gelatin microparticle composites. Therefore, TGF-β1 loaded composites and non-loaded controls were injected in circular defects as created in the femoral condyles of rabbits and we...


Mechanical evaluation of implanted calcium phosphate cement incorporated with P...

Link, Dennis P.; Van den Dolder, Juliette; Jurgens, J. F. M.; Wolke, Joop G.; Jansen, John A.

In this study, the mechanical properties of an implanted calcium phosphate (CaP) cement incorporated with 20wt% poly (DL-lactic-coglycolic acid) (PLGA) microparticles were investigated in a rat cranial defect. After 2, 4 and 8 weeks of implantation, implants were evaluated mechanically (push-out test) and morphologically (Scanning Electron Microscopy (SEM) and histology). The results of the push-out test showed...


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Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia