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Hydrogels for nucleus replacement : facing a biomechanical challenge
Reitmaier, S.; Wolfram, U.; Ignatius, A.; Wilke, H. - J.; Gloria, A.; Martín-Martínez, José M.; Correia, Joana Silva; Oliveira, Joaquim M.; Reis, R. L.Hydrogelsareconsideredpromisingfordiscregenerationstrategies.However,itiscurrently unknownwhetherthedestructionofthenaturalinterfacebetweennucleusandsurrounding structurescausedbynucleotomyandaninadequateannulusclosurediminishesthemechan- ical competenceofthedisc.This in vitro studyaimedtoclarifythesemechanismsandto evaluatewhetherhydrogelsareabletorestorethebiomechanicalbehaviourofthedisc. Nucleuspressureinano...
The effect of different defects and hydrogels for nucleus replacements on the b...
Reitmaier, Sandra; Wolfram, U.; Wilke, Hans-Joachim; Ignatius, Anita; Correia, Joana Silva; Oliveira, Joaquim M.; Reis, R. L.; Schmidt, HendrikPublicado em "Journal of Tissue Engineering and Regenerative Medicine", vol. 7, supp. 1 (2013) ; Hydrogels offer unique opportunities for regenerative strategies of the intervertebral disc. A nucleotomy necessary for the implantation of hydrogels, however, disrupts the annulus integrity and destroys natural interfaces in the disc. To clarify whether hydrogels can restore the mechanical competence of the disc a...
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