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Ursolic acid induces cell death and modulates autophagy through JNK pathway in ...
Xavier, Cristina P. R.; Lima, Cristóvão F.; Pedro, Dalila Fernanda Neto; Wilson, Jonathan M.; Kristiansen, K.; Wilson, Cristina PereiraColorectal carcinomas (CRCs) with P53 mutations have been shown to be resistant to chemotherapy with 5-fluorouracil (5-FU), the most widely used chemotherapeutic drug for CRC treatment. Autophagy is emerging as a promising therapeutic target for drug-resistant tumors. In the present study, we tested the effects of ursolic acid (UA), a natural triterpenoid, on cell death mechanisms and its effects in combination...
Rosmarinic acid, major phenolic constituent of Greek sage herbal tea, modulates...
Azevedo, Marisa; Lima, Cristóvão F.; Ferreira, Manuel Fernandes; Almeida, M. J.; Wilson, Jonathan M.; Wilson, Cristina PereiraScope: Previous results suggested that the effects of Salvia fruticosa tea (SFT) drinking on glucose regulation might be at the intestinal level. Here we aim to characterize the effects of SFT treatment and of its main phenolic constituent – rosmarinic acid (RA) – on the levels and localization of the intestinal Na+/glucose cotransporter-1 (SGLT1), the facilitative glucose transporter 2 and glucagon-like peptid...
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