Encontrados 43 documentos, a visualizar página 1 de 5

Ursolic acid induces cell death and modulates autophagy through JNK pathway in ...

Colorectal carcinomas (CRCs) with P53 mutations have been shown to be resistant to chemotherapy with 5-fluorouracil (5-FU), the most widely used chemotherapeutic drug for CRC treatment. Autophagy is emerging as a promising therapeutic target for drug-resistant tumors. In the present study, we tested the effects of ursolic acid (UA), a natural triterpenoid, on cell death mechanisms and its effects in combination...

Development of a new application of the comet assay to assess levels of O6-meth...

O6-methylguanine (O6meG) is one of the most premutagenic, precarcinogenic, and precytotoxic DNA lesions formed by alkylating agents. Repair of this DNA damage is achieved by the protein MGMT, which transfers the alkyl groups from the O6 position of guanine to a cysteine residue in its active center. Because O6meG repair by MGMT is a stoichiometric reaction that irreversibly inactivates MGMT, which is subsequent...

Hypericum androsaemum water extract inhibits proliferation in human colorectal ...

MAP kinase and PI3K/Akt signalling pathways are commonly altered in colorectal carcinoma (CRC) leading to tumor growth due to increased cell proliferation and inhibition of apoptosis. Several species of the genus Hypericum are used in Portugal to prepare herbal teas to which digestive tract effects are attributed. In the present study, the antiproliferative and proapoptotic effects of the water extracts of H. a...

Ursolic acid, a dietary phytochemical, decreases KRAS signaling and modulates c...

Publicado em "BMC Proceedings 2012, 6(Suppl 3)" ; KRAS mutations are frequent in colorectal cancer (CRC) and have the potential to activate proliferation and inhibit cell death through effects on MAPK/ERK and PI3K/Akt signaling pathways. Because diet is one of the most important determinants of CRC incidence and progression, we studied the effects of the dietary triterpenoid ursolic acid (UA) on proliferation ...

Induction of antioxidant defences by diterpenic phenolics in human fibroblasts ...

Ageing is characterised by the progressive accumulation of molecular damage, which leads to altered cellular functioning, reduced stress tolerance and susceptibility to diseases. Consumption of fruits, vegetables and herbs has been related with health promotion due to their content in bioactive phytochemicals, which can be used for ageing interventions [1]. In the present work, the ability of the phenolic diter...

Diet supplemented with UA or EGCG confer protection against DNA damage in colon...

Diet is an important factor in colorectal cancer. High fat diets are considered a risk factor for the development of colon cancer as they increase the content of bile acids in the colon. Bile acids have shown to induce the formation of reactive oxygen and nitrogen species, and these, in turn, induce DNA damage. On the other hand, diets rich in fruits and vegetables have shown preventive effects on colon cancer....

Diet and DNA damage : in vivo effects of dietary compounds on isolated colonocy...

Rosmarinic acid, major phenolic constituent of Greek sage herbal tea, modulates...

Scope: Previous results suggested that the effects of Salvia fruticosa tea (SFT) drinking on glucose regulation might be at the intestinal level. Here we aim to characterize the effects of SFT treatment and of its main phenolic constituent – rosmarinic acid (RA) – on the levels and localization of the intestinal Na+/glucose cotransporter-1 (SGLT1), the facilitative glucose transporter 2 and glucagon-like peptid...

Induction of cellular stress responses by phytochemicals for nutritional applic...

Aging is an important risk factor for the development of age-related diseases and is associated with decreased cellular antioxidant defenses and impaired stress responses, reducing the ability of cells to cope with stress. As xenobiotics, we hypothesize that, by imposing mild stress on human cells, antioxidant phytochemicals may afford anti-aging properties through induction of stress responses and cellular ant...

Induction of cellular stress responses by phytochemicals for nutritional applic...

Aging is an important risk factor for the development of age-related diseases and is associated with decreased cellular antioxidant defenses. Under the scope of the undergoing NaturAge project, our group is currently investigating the ability of some plant extracts and isolated phytochemicals to induce antioxidant defenses through Nrf2/ARE signaling. That, will be associated with possible anti-aging effects usi...