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Candida biofilms and oral candidosis : treatment and prevention

In recent years, there has been a significant increase in the incidence of human fungal infections (60). A number of factors have been implicated with this increase, but it is generally accepted that the main influences relate to the more widespread provision of new medical practices, such as immunosuppressive therapy and use of broad spectrum antibiotics, and invasive surgical procedures such as solid organ or...

Silicone colonization by non-Candida albicans Candida species in the presence o...

Urinary tract infections (UTIs) are the most common nosocomial infections and 80 % are related to the use of urinary catheters. Furthermore, Candida species are responsible for around 15 % of UTIs and an increasing involvement of non-Candida albicans Candida (NCAC) species (e.g. Candida glabrata, Candida tropicalis and Candida parapsilosis) has been recognized. Given the fact that silicone is frequently used in...

Colonization, invasion and damage of a reconstituted human oral epithelium by C...

Oral candisosis is a common problem in immunocompromised patients, and whilst Candida albicans is regarded as the principal cause of infection, other Candida species are increasingly being recognized as human pathogens. Moreover, relatively little is known about the role of Candida species in oral infections. Thus, this work aimed to examine Candida species infection of oral epithelium, and to assess their abil...

Adherence and biofilm formation of non-Candida albicans Candida species

Most cases of candidosis have been attributed to Candida albicans, but recently non-Candida albicans Candida species have been identified as frequent human pathogens. Candida pathogenicity has been attributed to several factors, including adhesion to medical devices and/or host cells, biofilm formation, and secretion of hydrolytic enzymes (proteases, phospholipases, and haemolysins). Although ‘new’ Candida spe...

Biofilms formation by Candida tropicalis and Candida parapsilosis on an in vitr...

The primary event in Candida infection is the colonization of host mucosal surfaces, often leading to the formation of biofilms. Most cases of candidosis have been attributed to Candida albicans, however, recently, non-Candida albicans Candida species have been identified as frequent pathogens of humans. Given the clinical importance of biofilm growth, the aim of this work was to study the biofilm formation by ...

Co-infection of an in vitro oral epithelium by Candida glabrata and Candida alb...

Candida albicans is regarded as the leading of cause of candidosis. However, Candida glabrata has emerged as an important pathogen of oral mucosa, occurring both singly or in mixed species infections, often with C. albicans. Compared with C. albicans, little is known about the role of C. glabrata in oral infection. Thus, this work aimed to examine single and mixed species infection of oral epithelium involvi...

The role of Candida species in colonization, invasion and damage of an in vitro...

The role of Candida species in colonization, invasion and damage of an in vitro r Oral candisosis is a common problem in immunocompromised patients, and whilst Candida albicans is regarded as the principal cause of infection, other Candida species are increasingly being recognized as human pathogens. Moreover, relatively little is known about the role of Candida species in oral infections. Thus, this work aimed...

Patterns of colonisation and invasion of oral mucosa by Candida tropicalis

In Vitro Biofilm Activity of Non-Candida albicans Candida Species

Candidosis has been attributed to C. albicans; however, infections caused by non-Candida albicans Candida (NCAC) species are increasingly being recognised. The ability of Candida to grow as a biofilm is an important feature that promotes both infection and persistence in the host. The biofilms’ activity is significant since high activity might be associated with enhanced expression of putative virulence factors...

Characterisation of Candida parapsilosis infection of an in vitro reconstituted...