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GABAA receptor dephosphorylation followed by internalization is coupled to neur...
Mele, Miranda; Ribeiro, Luís; Inácio, Ana R.; Wieloch, Tadeusz; Duarte, C. B.Cerebral ischemia is characterized by an early disruption of GABAergic neurotransmission contributing to an imbalance of the excitatory/inhibitory equilibriumand neuronal death, but the molecular mechanisms involved are not fully understood. Here we report a downregulation of GABAA receptor (GABAAR) expression, affecting both mRNA and protein levels of GABAAR subunits, in hippocampal neurons subjected to oxygen...
The temperature dependence and involvement of mitochondria permeability transit...
Rytter, Anna; Cardoso, Carla M. P.; Johansson, Petra; Cronberg, Tobias; Hansson, Magnus J.; Mattiasson, Gustav; Elmér, Eskil; Wieloch, TadeuszThe aggravating effect of hyperglycemia on ischemic brain injury can be mimicked in a model of in vitro ischemia (IVI) using murine hippocampal slice cultures. Using this model, we found that the damage in the CA1 region following IVI in the absence or presence of 40 mm glucose (hyperglycemia) is highly temperature dependent. Decreasing the temperature from 35 to 31°C during IVI prevented cell death, whereas in...
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