Encontrados 4 documentos, a visualizar página 1 de 1
The Impact of IPTi and IPTc Interventions on Malaria Clinical Burden – In Silic...
Águas, R.; Lourenço, J.M.L.; Gomes, M.G.M.; White, L.J.BACKGROUND: Clinical management of malaria is a major health issue in sub-Saharan Africa. New strategies based on intermittent preventive treatment (IPT) can tackle disease burden by simultaneously reducing frequency of infections and life-threatening illness in infants (IPTi) and children (IPTc), while allowing for immunity to build up. However, concerns as to whether immunity develops efficiently in treated i...
Prospects for malaria eradication in sub-Saharan Africa
Aguas, R.; White, L. J.; Snow R.W.; Gomes M.G.M.BACKGROUND: A characteristic of Plasmodium falciparum infections is the gradual acquisition of clinical immunity resulting from repeated exposures to the parasite. While the molecular basis of protection against clinical malaria remains unresolved, its effects on epidemiological patterns are well recognized. Accumulating epidemiological data constitute a valuable resource that must be intensively explored and i...
The reinfection threshold
Gomes, M. G. M.; White, L. J.; Medley, G. F.Thresholds in transmission are responsible for critical changes in infectious disease epidemiology. The epidemic threshold indicates whether infection invades a totally susceptible population. The reinfection threshold indicates whether self-sustained transmission occurs in a population that has developed a degree of partial immunity to the pathogen (by previous infection or vaccination). In models that combine...
Infection, reinfection, and vaccination under suboptimal immune protection: epi...
Gomes, M. G. M.; White, L. J.; Medley, G. F.The SIR (susceptible-infectious-resistant) and SIS (susceptible-infectious-susceptible) frameworks for infectious disease have been extensively studied and successfully applied. They implicitly assume the upper and lower limits of the range of possibilities for host immune response. However, the majority of infections do not fall into either of these extreme categories. We combine two general avenues that strad...
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