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Membrane Trafficking Machinery Components Associated with the Mammalian Acrosom...
Ramalho-Santos, João; Moreno, Ricardo D.; Wessel, Gary M.; Chan, Edward K. L.; Schatten, GeraldActive trafficking from the Golgi apparatus is involved in acrosome formation, both by delivering acrosomal contents to the nascent secretory vesicle and by controlling organelle growth and shaping. During murine spermiogenesis, Golgi antigens (giantin, [beta]-COP, golgin 97, mannosidase II) are detected in the acrosome until the late cap-phase spermatids, but are not found in testicular spermatozoa (maturation...
SNAREs in Mammalian Sperm: Possible Implications for Fertilization
Ramalho-Santos, João; Moreno, Ricardo D.; Sutovsky, Peter; Chan, Anthony Wing-Sang; Hewitson, Laura; Wessel, Gary M.; Simerly, Calvin R.Soluble N-ethylmalameide-sensitive factor attachment protein receptor (SNARE) proteins are present in mammalian sperm and could be involved in critical membrane fusion events during fertilization, namely the acrosome reaction. Vesicle-associated membrane protein/synaptobrevin, a SNARE on the membrane of a vesicular carrier, and syntaxin 1, a SNARE on the target membrane, as well as the calcium sensor synaptotag...
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