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How Small Polar Molecules Protect Membrane Systems against Osmotic Stress: The ...
Costa-Balogh, Fátima O.; Wennerström, Hakan; Wadsö, Lars; Sparr, EmmaWe investigate how a small polar molecule, urea, can act to protect a phospholipid bilayer system against osmotic stress. Osmotic stress can be caused by a dry environment, by freezing, or by exposure to aqueous systems with high osmotic pressure due to solutes like in saline water. A large number of organisms regularly experience osmotic stress, and it is a common response to produce small polar molecules intr...
The Hydration of a DNA−Amphiphile Complex
Leal, Cecilia; Wadsö, Lars; Olofsson, Gerd; Miguel, Maria; Wennerström, HåkanWe present measurements of isothermal DNA−hexadecyltrimethylammonium (DNACTA) complex and pure DNA hydration at 25 °C using a sorption microcalorimeter. This calorimeter provides simultaneous measurement of (i) water activity (sorption isotherms) and (ii) the partial molar enthalpy of water as a function of water uptake. For pure DNA, hydration is exothermic over the studied concentration range and we find an a...
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