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A mechanistic paradigm for broad-spectrum antivirals that target virus-cell fusion
Vigant, Frederic; Lee, Jihye; Hollmann, Axel; Tanner, Lukas B.; Ataman, Zeynep Akyol; Yun, Tatyana; Shui, Guanghou; Aguilar, Hector C.; Zhang, Dong© 2013 Vigant et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ; LJ001 is a lipophilic thiazolidine derivative that inhibits the entry of numerous enveloped viruses at non-cytotoxic concentrations (IC50≤0.5 mM), and was...
Comparative lipidomic analysis of mouse and human brain with Alzheimer disease
Chan, Robin B.; Oliveira, Tiago Gil; Cortes, Etty P.; Honig, Lawrence S.; Duff, Karen E.; Small, Scott A.; Wenk, Markus R.; Shui, GuanghouLipids are key regulators of brain function and have been increasingly implicated in neurodegenerative disorders including Alzheimer disease (AD). Here, a systems-based approach was employed to determine the lipidome of brain tissues affected by AD. Specifically, we used liquid chromatography-mass spectrometry to profile extracts from the prefrontal cortex, entorhinal cortex, and cerebellum of late-onset AD (LO...
Phospholipase d2 ablation ameliorates Alzheimer's disease-linked synaptic dysfu...
Oliveira, Tiago Gil; Chan, Robin B.; Tian, Huasong; Laredo, Mikael; Shui, Guanghou; Staniszewski, Agnieszka; Zhang, Hong; Wang, Lili; Kim, Tae-WanGrowing evidence implicates aberrant lipid signaling in Alzheimer's disease (AD). While phospholipases A2 and C have been recently shown to mediate key actions of amyloid ??-peptide (A??) through a dysregulation of arachidonic acid and phosphatidylinositol-4,5-bisphosphate metabolism, respectively, the role of phospholipase D (PLD) has so far remained elusive. PLD produces phosphatidic acid (PA), a bioactive li...
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