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Caloric restriction or catalase inactivation extends yeast chronological lifesp...
Mesquita, Ana Maria Macedo; Weinberger, Martin; Silva, Alexandra; Marques, Belém Sampaio; Almeida, Bruno; Leão, Cecília; Costa, VitorThe free radical theory of aging posits oxidative damage to macromolecules as a primary determinant of lifespan. Recent studies challenge this theory by demonstrating that in some cases, longevity is enhanced by inactivation of oxidative stress defenses or is correlated with increased, rather than decreased reactive oxygen species and oxidative damage. Here we show that, in Saccharomyces cerevisiae, caloric res...
Growth signaling promotes chronological aging in budding yeast by inducing supe...
Weinberger, Martin; Mesquita, Ana Maria Macedo; Carroll, Timothy; Marks, Laura; Hui Yang; Zhaojie Zhang; Ludovico, Paula; Burhans, William CInhibition of growth signaling pathways protects against aging and age-related diseases in parallel with reduced oxidative stress. The relationships between growth signaling, oxidative stress and aging remain unclear. Here we report that in Saccharomyces cerevisiae, alterations in growth signaling pathways impact levels of superoxide anions that promote chronological aging and inhibit growth arrest of stationar...
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