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GM1 improves neurofascin155 association with lipid rafts and prevents rat brain...

Zhang,Y.P.; Huang,Q.L.; Zhao,C.M.; Tang,J.L.; Wang,Y.L.

White matter injury characterized by damage to myelin is an important process in hypoxic-ischemic brain damage (HIBD). Because the oligodendrocyte-specific isoform of neurofascin, neurofascin 155 (NF155), and its association with lipid rafts are essential for the establishment and stabilization of the paranodal junction, which is required for tight interaction between myelin and axons, we analyzed the effect of...

Data: 2011   |   Origem: OASIS br

Clustering of psychiatric and somatic illnesses in the general population: mult...

Andrade,L.H.; Benseñor,I.M.; Viana,M.C.; Andreoni,S.; Wang,Y.-P.

The distribution of psychiatric disorders and of chronic medical illnesses was studied in a population-based sample to determine whether these conditions co-occur in the same individual. A representative sample (N = 1464) of adults living in households was assessed by the Composite International Diagnostic Interview, version 1.1, as part of the São Paulo Epidemiological Catchment Area Study. The association of ...

Data: 2010   |   Origem: OASIS br

Prognosis of colorectal cancer with liver metastasis: value of a prognostic index

Wang,Y.; Liu,Y.F.; Cheng,Y.; Yi,D.H.; Li,P.; Song,W.Q.; Fu,D.Z.; Wang,X.

The objective of the present study was to explore the factors related to the prognosis of colorectal cancer (CRC) and to establish a prognostic model for the selection of patients who might benefit from hepatic resection for metastatic CRC. A total of 293 patients undergoing liver resection for metastatic CRC (172 males and 80 females ranging in age from 26 to 80 years) were selected and clinical, pathological ...

Data: 2010   |   Origem: OASIS br

High expression of the circadian gene mPer2 diminishes the radiosensitivity of ...

Chang,L.; Liu,Y.Y.; Zhu,B.; Li,Y.; Hua,H.; Wang,Y.H.; Zhang,J.; Jiang,Z.; Wang,Z.R.

Period2 is a core circadian gene, which not only maintains the circadian rhythm of cells but also regulates some organic functions. We investigated the effects of mPeriod2 (mPer2) expression on radiosensitivity in normal mouse cells exposed to 60Co-γ-rays. NIH 3T3 cells were treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) to induce endogenous mPer2 expression or transfected with pcDNA3.1(+)-mPer2 a...

Data: 2009   |   Origem: OASIS br

Investigation of the stress and strain state of clay pipes under fire condition

Ding Yining; Wang, Y.; Zhang Yulin; Paulini, P

The focus of this paper is given to investigating the testing and evaluation method of stress and deformation behaviour of clay pipe elements like chimneys under cyclic high temperature. The experimental study on the temperature–time curves and on the radial deformation–temperature curves of a series of fire-resistant clay pipes was carried out. The tensile strength and the compressive strength, the elastic mod...


A double-blind comparison of the effect of the antipsychotics haloperidol and o...

Moreno,R.A.; Hanna,M.M.; Tavares,S.M.; Wang,Y .P.

The effects of haloperidol and olanzapine on polysomnographic measures made in bipolar patients during manic episodes were compared. Twelve DSM-IV mania patients were randomly assigned to receive either haloperidol (mean ± SD final dosage: 5.8 ± 3.8 mg) or olanzapine (mean ± SD final dosage: 13.6 ± 6.9 mg) in a 6-week, double-blind, randomized, controlled clinical trial. One-night polysomnographic evaluation wa...

Data: 2007   |   Origem: OASIS br

Dimensionality of the premenstrual syndrome: confirmatory factor analysis of pr...

Wang,Y.-P.; Teng,C.-T.; Vieira Filho,A.H.G.; Gorenstein,C.; Andrade,L.H.

Premenstrual syndrome and premenstrual dysphoric disorder (PMDD) seem to form a severity continuum with no clear-cut boundary. However, since the American Psychiatric Association proposed the research criteria for PMDD in 1994, there has been no agreement about the symptomatic constellation that constitutes this syndrome. The objective of the present study was to establish the core latent structure of PMDD symp...

Data: 2007   |   Origem: OASIS br

In vitro monitoring of surface mechanical properties of poly(L-lactic acid) usi...

Saiz-Arroyo, C.; Wang, Y.; Rodriguez-Perez, M. A.; Alves, N. M.; Mano, J. F.

Poly(L-lactic acid) (PLLA) was immersed in a simulated body fluid (SBF) solution at 37.58C for distinct times. The variation of the surface mechanical properties of PLLA samples with immersion time was followed by microhardness. These measurements showed that PLLA microhardness decreased significantly ( 60%) after only 30 days of immersion. The results were explained in terms of hydrolytic degradation of the s...


Influence of PLLA molecular weight and cristalinity on the adhesion and prolife...

Salgado, A. J.; Wang, Y.; Mano, J. F.; Reis, R. L.

The molecular weight and crystallinity of systems based on poly(L-lactic acid) PLLA is an important issue as it can influence, besides the general physical properties of the polymer, the patterns of cell adhesion, proliferation and cell morphology. The objective of the present study was to evaluate how crystallinity and molecular weight of PLLA influence the referred parameters. Four conditions were tested: low...


Validation of the Beck Depression Inventory for a Portuguese-speaking Chinese c...

Wang,Y.-P.; Andrade,L.H.; Gorenstein,C.

The objective of the present study was to investigate the psychometric properties and cross-cultural validity of the Beck Depression Inventory (BDI) among ethnic Chinese living in the city of São Paulo, Brazil. The study was conducted on 208 community individuals. Reliability and discriminant analysis were used to test the psychometric properties and validity of the BDI. Principal component analysis was perform...

Data: 2005   |   Origem: OASIS br

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    Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia