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Characterization of modular bacteriophage endolysins from Myoviridae phages OBP...
Walmagh, Maarten; Briers, Yves; Santos, Sílvio; Azeredo, Joana; Lavigne, RobPeptidoglycan lytic enzymes (endolysins) induce bacterial host cell lysis in the late phase of the lytic bacteriophage replication cycle. Endolysins OBPgp279 (from Pseudomonas fluorescens phage OBP), PVP-SE1gp146 (Salmonella enterica serovar Enteritidis phage PVP-SE1) and 201φ2-1gp229 (Pseudomonas chlororaphis phage 201φ2-1) all possess a modular structure with an N-terminal cell wall binding domain and a C-ter...
Characterization of modular bacteriophage endolysins from giant phiKZ related m...
Walmagh, Maarten; Briers, Briers; Santos, Sílvio; Azeredo, Joana; Lavigne, RobPeptidoglycan lytic enzymes (endolysins) of bacteriophages have a major role in bacterial lysis at the end of the phage replication cycle. These endolysins turned out to be potential antibacterial compounds to combat a broad range of Gram-positive pathogens, yet Gram-negative bacteria remain unharmed due to their impermeable outer membrane. With this background, we recently characterized three new endolysins fr...
Antibacterial activity on opportunistic Pseudomonas aeruginosa pathogen by a no...
Oliveira, Hugo; Walmagh, Maarten; Kluskens, Leon; Sillankorva, Sanna; Lavigne, Rob; Azeredo, JoanaThe Gram-negative pathogen Pseudomonas aeruginosa can cause severe infections of burn wound or cystic fibrosis on patients. Bacteriophage endolysin based strategy can offer a new alternative antimicrobial therapy. Endolysins are lytic enzymes that break down the peptidoglycan of bacterial cell wall at the late phage lytic cycle, however they are inactive on their own against Gram-negative bacteria when applied ...
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