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Carvedilol Protects against Doxorubicin-Induced Mitochondrial Cardiomyopathy
Santos, D. L.; Moreno, A. J. M.; Leino, R. L.; Froberg, M. K.; Wallace, K. B.Several cytopathic mechanisms have been suggested to mediate the dose-limiting cumulative and irreversible cardiomyopathy caused by doxorubicin. Recent evidence indicates that oxidative stress and mitochondrial dysfunction are key factors in the pathogenic process. The objective of this investigation was to test the hypothesis that carvedilol, a nonselective [beta]-adrenergic receptor antagonist with potent ant...
Induction of the Mitochondrial Permeability Transition in Vitro by Short-Chain ...
Palmeira, C. M.; Rana, M. I.; Frederick, C. B.; Wallace, K. B.We recently reported that acrylic acid (AA) induces the MPT in vitro, which we suggested might be a critical event in the acute inflammatory and hyperplastic response of the olfactory epithelium. The purpose of the present investigation was to determine if induction of the MPT is a general response to short-chain carboxylic acids or if there are critical physical chemical parameters for this response. Freshly i...
Cardioselective and cumulative oxidation of mitochondrial DNA following subchro...
Serrano, J.; Palmeira, C. M.; Kuehl, D. W.; Wallace, K. B.We recently reported the preferential accumulation of 8-hydroxydeoxyguanosine (8OHdG) adducts in cardiac mitochondrial DNA (mtDNA) following acute intoxication of rats with doxorubicin (C.M. Palmeira et al., Biochim. Biophys. Acta, 1321 (1997) 101-106). The concentration of 8OHdG adducts decreased to control values within 2 weeks. Since conventional antineoplastic therapy entails repeated administration of smal...
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