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Lymphatic vessel density and VEGF-C expression are significantly different amon...
Garcia, Eduardo Anselmo; Simões, Kleber; Wakamatsu, Alda; Ressio, Rodrigo Albergaria; Alves, Venâncio Avancini Ferreira; Longatto Filho, AdhemarThyroid cancer is the most frequent endocrine neoplasia worldwide. The route for metastasis and loco-regional invasion preferentially occurs by lymphatic vessels. For this reason, the assessment of lymphatic vessel density (LVD) is supposed to represent both a prognostic parameter and also a potential therapeutic target. In order to evaluate the value of LVD in benign and malignant thyroid lesions, we analyzed ...
Immunocytochemical expression of p16 INK4A and Ki-67 in cytologically negative ...
Longatto Filho, Adhemar; Utagawa, Maria Lúcia; Shirata, Neuza Kasumi; Pereira, Sónia Maria Miranda; Namiyama, Gislene; Kanamura, Cristina TakamiThis study was designed to analyze the cross-sectional comparison of the p16 INK4A and Ki-67 immunocytochemical expression in negative and equivocal (atyp-ical squamous cells of undetermined significance (ASC-US)) liquid-based cytology (LBC) samples testing positive for high-risk human papillomavirus (HPV) types with HC2 assay or polymerase-chain reaction (PCR). A series of 199 consecutive LBC speci-mens derive...
p53 immunostaining pattern in Brazilian patients with hepatocellular carcinoma
Alves,Venâncio Avancini Ferreira; Nita,Marcelo Eidi; Carrilho,Flair José; Ono-nita,Suzane Kioko; Wakamatsu,Alda; Lehrbach,Dárcio MatenhauerHepatocellular carcinoma (HCC) is an important type of cancer etiologically related to some viruses, chemical carcinogens and other host or environmental factors associated to chronic liver injury in humans. The tumor suppressor gene p53 is mutated in highly variable levels (0-52%) of HCC in different countries. OBJECTIVE: The objective of the present study was to compare the frequency of aberrant immunohistoch...
Inflammatory fibroid polyp: an immunohistochemical study
Santos,Gilda da Cunha; Alves,Venâncio A.F.; Wakamatsu,Alda; Zucoloto,SérgioBACKGROUND: Inflammatory fibroid polyp is a localized lesion, which arises in the submucosa of the gastrointestinal tract, most often in the stomach.Although it is generally believed to represent a reactive, nonneoplastic condition, its histogenesis remains controversial. AIM: To study inflammatory fibroid polyp by immunohistochemistry in an attempt to further clarify their histogenesis. MATERIAL AND METHODS: N...
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