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Development of silk-based scaffolds for tissue engineering of bone from human a...
Correia, Cristina; Bhumiratana, Sarindr; Yan, Leping; Oliveira, A. L.; Gimble, Jeffrey M.; Rockwood, Danielle; Kaplan, David; Sousa, R. A.; Reis, R. L.Silk fibroin is a potent alternative to other biodegradable biopolymers for bone tissue engineering (TE), because of its tunable architecture and mechanical properties, and its demonstrated ability to support bone formation both in vitro and in vivo. In this study, we investigated a range of silk scaffolds for bone TE using human adipose-derived stem cells (hASCs), an attractive cell source for engineering auto...
In vitro model of vascularized bone : synergizing vascular development and oste...
Correia, Cristina; Grayson, W. L.; Park, Miri; Hutton, Daphne; Zhou, Bin; Guo, X. Edward; Niklason, Laura; Sousa, R. A.; Reis, R. L.Tissue engineering provides unique opportunities for regenerating diseased or damaged tissues using cells obtained from tissue biopsies. Tissue engineered grafts can also be used as high fidelity models to probe cellular and molecular interactions underlying developmental processes. In this study, we co-cultured human umbilical vein endothelial cells (HUVECs) and human mesenchymal stem cells (MSCs) under variou...
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