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Conformational stability of ibuprofen: Assessed by DFT calculations and optical...
Vueba, M. L.; Pina, M. E.; Carvalho, L. A. E. Batista deA thorough conformational analysis of ibuprofen [2-(4-isobutylphenyl) propionic acid] was carried by out, using density functional theory (DFT) calculations coupled to optical vibrational spectroscopy (both Raman and FTIR). Eight different geometries were found to be energy minima. The relative orientations of the substituent groups in the ibuprofen molecule, which can be considered as a para-substituted phenyl...
Conformational study of ketoprofen by combined DFT calculations and Raman spect...
Vueba, M. L.; Pina, M. E.; Veiga, F.; Sousa, J. J.; Carvalho, L. A. E. Batista deA conformational study of ketoprofen was carried out by both density functional theory (DFT) calculations and Raman spectroscopy. Nine different geometries were found to correspond to energy minimum conformations but only one of them was experimentally detected in the condensed phase spectra. ; http://www.sciencedirect.com/science/article/B6T7W-4HGM796-2/1/6cedf602b0e0b1233ab158acd2f80f23
Influence of Cellulose Ether Mixtures on Ibuprofen Release: MC25, HPC and HPMC ...
Vueba, M. L.; Carvalho, L. A. E. Batista de; Veiga, F.; Sousa, J. J.; Pina, M. E.The influence of cellulose ether derivatives on ibuprofen release from matrix tablets was investigated. Raman spectroscopy and differential scanning calorimetry (DSC) experiments were used, in order to examine the compatibility between the matrix components: both excipients and ibuprofen. While both the DSC and Raman results did not detect any incompatibilities, DSC revealed the existence of some drug:excipient...
Influence of cellulose ether polymers on ketoprofen release from hydrophilic ma...
Vueba, M. L.; Carvalho, L. A. E. Batista de; Veiga, F.; Sousa, J. J.; Pina, M. E.The present work reports the study of different ketoprofen:excipient formulations, in order to determine the effect of the polymer substitution and type of diluent on the drug-release mechanism. Substituted cellulose--methylcellulose, hydroxypropylcellulose and hydroxypropylmethylcellulose were used as polymers, while lactose monohydrate and [beta]-cyclodextrin were tested as diluents. Distinct test formulation...
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