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Influência do butorfanol sobre os períodos de latência e de ação da ropivacaína...
Albuquerque,V.B.; Souza,T.F.B.; Vivan,M.C.R.; Ferreira,J.Z.; Frade,M.C.; Perri,S.H.V.; Oliva,V.N.L.S.Avaliaram-se os períodos de latência e de duração do efeito do butorfanol associado à ropivacaína aplicados pela via peridural e a possibilidade de uso dessa associação como protocolo anestésico para realização de ovariossalpingo-histerectomia (OSH) em cadelas. Utilizaram-se 16 cadelas pré-medicadas com acepromazina e midazolam compondo dois grupos: no grupo 1 (n=8) aplicou-se ropivacaína isolada (0,3mL/kg) e n...
Electrochemical detection of in situ adriamycin oxidative damage to DNA
Oliveira-Brett, A. M.; Vivan, M.; Fernandes, I. R.; Piedade, J. A. P.Adriamycin intercalation and in situ interaction with double helix DNA was investigated using a voltammetric DNA-biosensor. Oxidation and reduction of adriamycin molecules intercalated in double helix DNA were investigated in order to understand the in vivo mechanism of action with this anti-neoplasic drug. The results showed that the interaction of adriamycin with DNA is potential-dependent causing contact bet...
Genetic polymorphism of CYP2D6, GSTM1 and NAT2 and susceptibility to haematolog...
Lemos, M. C.; Cabrita, F. J.; Silva, H. A.; Vivan, M.; Plácido, F.; Regateiro, F. J.Xenobiotic-metabolizing enzymes constitute an important line of defence against a variety of carcinogens. Many are polymorphic, constituting the basis for the wide inter-individual variation in metabolic capacity and possibly a source of variation in the susceptibility to chemical-induced carcinogenesis. The aim of this study was to determine the existence of any association between the main genetic polymorphis...
Genetic polymorphism of CYP2D6, GSTM1 and NAT2 and susceptibility to haematolog...
Lemos, MC; Cabrita, FJ; Silva, HA; Vivan, M; Plácido, F; Regateiro, FJXenobiotic-metabolizing enzymes constitute an important line of defence against a variety of carcinogens. Many are polymorphic, constituting the basis for the wide inter-individual variation in metabolic capacity and possibly a source of variation in the susceptibility to chemical-induced carcinogenesis. The aim of this study was to determine the existence of any association between the main genetic polymorphis...
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