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The ulcerogenic profile of Helicobacter pylori paediatric strains associated wi...

Vitoriano, Inês; Saraiva-Pava, Kathy; Rocha-Gonçalves, António; Alves-Matos, Pedro; Vale, Filipa; Santos, Andrea; Lopes, Ana Isabel; Oleastro, Mónica

Helicobacter pylori infection is the major cause of paediatric peptic ulcer disease (PUD). In children with no other aetiology for the disease, this rare event occurs shortly after infection, presuming a still poorly understood higher susceptibility of the patient and highlighting the virulence of the implicated strain. Recently, we showed that the enhanced virulence of a group of paediatric ulcerogenic-strains...


Ulcerogenic Helicobacter pylori Strains Isolated from Children: A Contribution ...

Vitoriano, Inês; Saraiva-Pava, Kathy; Rocha-Gonçalves, Alexandra; Santos, Andrea; Lopes, Ana Isabel; Oleastro, Mónica; Roxo-Rosa, Mónica

Infection with Helicobacter pylori is the major cause for the development of peptic ulcer disease (PUD). In children, with no other etiology for the disease, this rare event occurs shortly after infection. In these young patients, habits of smoking, diet, consumption of alcohol and non-steroid anti-inflammatory drugs and stress, in addition to the genetic susceptibility of the patient, represent a minor influ...


Proteome analysis of clustered helicobacter pylori strains

Vitoriano, Inês; Vítor, Jorge; Oleastro, Mónica; Roxo-Rosa, Mónica; Vale, Filipa

Genomic-methylation typing method, based on strains’ Restriction/Modification systems, confirmed the genetic variability of Helicobacter pylori. According to this, strains isolated from patients of the same family, or from the same geographic region, cluster together. The analysis of proteome’s variability of these clusters has been a missing topic. We applied the Minimum-Common-Restriction-Modification (MCRM) ...


Ulcerogenic profile of helicobacter pylori pediatric strains: a contribution to...

Vitoriano, Inês; Saraiva-Pava, Kathy; Rocha-Gonçalves, Alexandra; Santos, Andrea; Lopes, Ana Isabel; Oleastro, Mónica; Roxo-Rosa, Mónica


MYH associated polyposis: severe phenotype in the homozygosity for the 1103delC...

De Ferro, Susana Mão; Lage, Pedro; Suspiro, Alexandra; Fidalgo, Paulo; Fragoso, Sofia; Baltazar, Célia; Vitoriano, Inês; Rodrigues, Paula

MYH-associated polyposis (MAP) is an autosomal recessive disease associated with multiple colonic adenomas and colorectal cancer. Y165C and G382D MYH missense mutations are involved in more than 80% of cases in Caucasians and the large series published do not include patients homozygous for other mutations. We present the report of two siblings homozygous for the nonsense frameshift mutation 1103delC. The proba...

Data: 2007   |   Origem: Acta Médica Portuguesa

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    Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia