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The Sensitizers Nickel Sulfate and 2,4-dinitrofluorobenzene Increase CD40 and I...
Vital, Ana Luísa; Gonçalo, Margarida; Cruz, Maria Teresa; Figueiredo, Américo; Duarte, Carlos B.; Lopes, Maria CelesteDendritic cells (DCs) are antigen-presenting cells (APCs) capable of capturing haptens and to process and present them to T lymphocytes. In order to sensitize T cells for contact hypersensitivity (CHS), skin DCs suffer a maturation process with modifications on their surface molecules. The aim of this work was to evaluate changes induced by two contact sensitizers, 2,4-dinitrofluorobenzene (DNFB) and nickel sul...
Dexamethasone prevents granulocyte-macrophage colonystimulating factor-induced ...
Vital, Ana Luísa; Gonçalo, Margarida; Cruz, M. Teresa; Figueiredo, Américo; Duarte, Carlos B.; Lopes, M. CelesteAIMS: Nitric oxide (NO) has been increasingly implicated in inflammatory skin diseases, namely in allergic contact dermatitis. In this work, we investigated the effect of dexamethasone on NO production induced by the epidermal cytokine granulocyte / macrophage colony-stimulating factor (GM-CSF) in a mouse fetal skin dendritic cell line.Methods: NO production was assessed by the method of Griess. Expression of t...
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