Encontrados 4 documentos, a visualizar página 1 de 1
Amplified and Homozygously Deleted Genes in Glioblastoma: Impact on Gene Expres...
Crespo, I; Tão, H; Nieto, AB; Rebelo, O; Domingos, P; Vital, AL; Patino, MC; Barbosa, MD; Lopes, MC; Resende de Oliveira, C; Orfão, A; Tabernero, MDBACKGROUND: Glioblastoma multiforme (GBM) displays multiple amplicons and homozygous deletions that involve relevant pathogenic genes and other genes whose role remains unknown. METHODOLOGY: Single-nucleotide polymorphism (SNP)-arrays were used to determine the frequency of recurrent amplicons and homozygous deletions in GBM (n = 46), and to evaluate the impact of copy number alterations (CNA) on mRNA levels of...
Intratumoral patterns of clonal evolution in gliomas
Vital, AL; Tabernero, MD; Crespo, I; Rebelo, O; Tão, H; Gomes, F; Lopes, MC; Orfão, AFew studies have explored the patterns of clonal evolution in gliomas. Here, we investigate the cytogenetic patterns of intratumoral clonal evolution of gliomas and their impact on tumor histopathology and patient survival. Cytogenetic analysis of 90 gliomas was performed in individual tumor cells (>200 cells/tumor) using multicolor (N = 16 probes) interphase-FISH. Overall, chromosome gains were more frequent t...
The sensitizers nickel sulfate and 2,4-dinitrofluorobenzene increase CD40 and I...
Vital, AL; Gonçalo, Margarida; Cruz, MT; Figueiredo, A; Duarte, CB; Lopes, MCDendritic cells (DCs) are antigen-presenting cells (APCs) capable of capturing haptens and to process and present them to T lymphocytes. In order to sensitize T cells for contact hypersensitivity (CHS), skin DCs suffer a maturation process with modifications on their surface molecules. The aim of this work was to evaluate changes induced by two contact sensitizers, 2,4-dinitrofluorobenzene (DNFB) and nickel sul...
Dexamethasone prevents granulocyte-macrophage colony-stimulating factor-induced...
Vital, AL; Gonçalo, Margarida; Cruz, MT; Figueiredo, A; Duarte, CB; Lopes, MCAIMS: Nitric oxide (NO) has been increasingly implicated in inflammatory skin diseases, namely in allergic contact dermatitis. In this work, we investigated the effect of dexamethasone on NO production induced by the epidermal cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) in a mouse fetal skin dendritic cell line. METHODS: NO production was assessed by the method of Griess. Expression of th...
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