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Phenylpyrazolone derivatives inhibit gastric emptying in rats by a capsaicin-se...
Vinagre,A.M.; Collares,E.F.Dipyrone (Dp), 4-aminoantipyrine (AA) and antipyrine (At) administered iv and Dp administered icv delay gastric emptying (GE) in rats. The participation of capsaicin (Cps)-sensitive afferent fibers in this phenomenon was evaluated. Male Wistar rats were pretreated sc with Cps (50 mg/kg) or vehicle between the first and second day of life and both groups were submitted to the eye-wiping test. GE was determined i...
Effect of 4-aminoantipyrine on gastric compliance and liquid emptying in rats
Vinagre,A.M.; Collares,E.F.Dipyrone (Dp) delays gastric emptying (GE) in rats. There is no information about whether 4-aminoantipyrine (AA), one of its metabolites, has the same effect. The objectives of the present study were to assess the effects of AA and Dp on GE when administered intravenously (iv) and intracerebroventricularly (icv) (240 µmol/kg and 4 µmol/animal, respectively) and on gastric compliance when administered iv (240 µm...
Aplicação SIG ao Ordenamento do Território na frente urbana de Espinho : uma pr...
Pires, Ana; Vinagre, A.; Gomes, António Alberto; Chaminé, Helder I.This study was based on a historical research and a detailed analysis of aerial photos of the littoral of Espinho (NW Portugal), as well as on field inquiries to the local population. The data gathered allowed an analysis of the Espinho dynamic coastal system since the XIX Century, and the inference of its evolution as a useful tool for the management of the coastal urban landscape. A historical reconstitution ...
Effect of antipyrine on the gastric emptying of liquid in rats
Soares,A.C.F.; Vinagre,A.M.; Collares,E.F.Antipyrine (At) and dipyrone (Dp) delay gastric emptying (GE) in rats. The objective of the present study was to assess the effects of intravenous (iv) and intracerebroventricular (icv) administration of At and Dp on the GE of liquid by rats. GE was assessed in male Wistar rats (5-10 in each group) 10 min after the icv or iv drug injection by measuring percent gastric retention (%GR) of a saline test meal label...
Effect of the GABA B agonist baclofen on dipyrone-induced delayed gastric empty...
Collares,E.F.; Vinagre,A.M.Dipyrone administered intravenously (iv) or intracerebroventricularly (icv) delays gastric emptying (GE) in rats. Gamma-aminobutyric acid (GABA) is the most potent inhibitory neurotransmitter of the central nervous system. The objective of the present study was to determine the effect of icv baclofen, a GABA B receptor agonist, on delayed GE induced by dipyrone. Adult male Wistar rats received a saline test mea...
Evidence of the effect of dipyrone on the central nervous system as a determina...
Collares,E.F.; Vinagre,A.M.Dipyrone administered intravenously (iv) delays gastric emptying (GE) in rats. The objectives of the present study were to assess: 1) the effect of the dose of dipyrone and time after its iv administration on GE in rats, 2) the effect of subdiaphragmatic vagotomy (VgX) and bilateral electrolytic lesion of the paraventricular nucleus (PVNX) on the delayed GE induced by the drug, and 3) the intracerebroventricula...
Effect of toxin-g from Tityus serrulatus scorpion venom on gastric emptying in ...
Bucaretchi,F.; Vinagre,A.M.; Chavéz-Olórtegui,C.; Collares,E.F.The effect of toxin-<FONT FACE="Symbol">g</font> from Tityus serrulatus scorpion venom on the gastric emptying of liquids was studied in 176 young adult male Wistar rats (2-3 months of age) divided into subgroups of 8 animals each. Toxin-<FONT FACE="Symbol">g</font> was injected iv at doses of 25, 37.5, 50 or 100 µg/kg and the effect on gastric emptying was assessed 30 min and 8 h later. A time-course study was...
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