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N-glicosilação do recetor das células t: um novo mecanismo molecular na patogén...

Polymeric nanogels as vaccine delivery systems

Polymeric nanogels find a relevant field of application in the formulation of a new generation of therapeutic and preventive vaccines, aiming at the fine-tuned modulation of the immune response. Intrinsic properties of polymeric nanogels, such as material chemistry, size and shape, surface charge, and hydrophobicity or hydrophilicity, may be determining factors in shaping the induced immune response. These mate...

Monoclonal antibody raised against PNAG has variable effects on static S. epide...

Global transcriptomic analysis of dormancy within Staphylococcus epidermidis bi...

Genotypic and phenotypic differences between nosocomial and commensal Staphyloc...

Staphylococcus epidermidis is a common causative agent of relapsing and persistent hospital-acquired infections, not only because this bacterium belongs to the patients’ microbiota(causing autoinfection) but also because it is easily transmitted by healthcare workers (causing cross-infections). The goal of the present study was to characterize, for the first time, the biofilm-forming ability and virulence assoc...

Whole transcriptome analysis of Staphylococcus epidermidis biofilms upon contac...

Staphylococcus epidermidis is commonly associated with foreign body infections due to its ability to form biofilms on the surface of indwelling medical devices. Understanding how the biofilms form on the top of devices and interact with the host, particularly, with human blood components, is of great interest. Here we assessed the whole transcriptome of S. epidermidis biofilms upon contact with human blood. Est...

A first new look into the interaction of Staphylococcus epidermidis biofilm-rel...

The widespread application of indwelling medical devices in the clinical setting, together with the remarkable ability of the commensal Staphylococcus epidermidis to adhere to these surfaces and form biofilms, has given to this bacterium the recognition of being a leading causative agent of nosocomial infections. Biofilms lifecycle is currently divided into 4 main steps: initial adhesion, accumulation, maturati...

Genomic characterization of the Staphylococcus epidermidis-specific bacteriopha...

Staphylococcus epidermidis is one of the most frequent causative agents of nosocomial infections, predominantly in patients with indwelling medical devices. This microrganism may form biofilms which are microbial structures very tolerant to the host immune defenses and to antibiotherapy. Therefore, studies are needed in order to develop effective methods for biofilm control. Currently, bacteriophages (phages) a...

Medium supplementation with magnesium prevented the induction of dormancy in bi...

Staphylococcus epidermidis is a commensal bacterium that colonizes the skin and mucous membranes, being the most prevalent staphylococcal species found in humans. However, S. epidermidis has the ability of colonize indwelling medical devices establishing biofilms, which makes this bacteria a common cause of bacteraemia particularly in immunocompromised individuals and neonates [1][2]. The presence of high amoun...

Bacterial cellulose : long-term biocompatibility studies

The bacterial cellulose (BC) secreted by G. xylinus is a network of pure cellulose nanofibers, which has high crystallinity, wettability and mechanical strength. These characteristics make BC an excellent material for tissue engineering constructs, noteworthy for artificial vascular grafts. In this work, the in vivo biocompatibility of BC membranes produced by two G. xylinus strains was analyzed through histolo...