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Evaluation of the protective effect of Hypericum perforatum phenolics compounds...
Vieira, Pedro Miguel de Sousa; Marques, Belém Sampaio; Ludovico, Paula; Dias, Alberto Carlos PiresParkinson’s disease (PD), first described by James Parkinson in 1817, is a chronic, progressive neurodegenerative disorder. The pathologic hallmark is a deterioration of the substantia nigra of yet unknown causes, resulting in a deficiency of dopamine, an important neurotransmitter for the basal ganglia circuit and the presence of cytoplasmic eosinophilic inclusions named Lewy ...
Hypericum perforatum phenolics compounds : protective role in the toxicity indu...
Vieira, Pedro Miguel de Sousa; Marques, Belém Sampaio; Ludovico, Paula; Dias, Alberto Carlos PiresParkinson’s disease (PD) is a neurodegenerative disorder with high prevalence and is characterized by the loss of dopaminergic neurons and the presence of cytoplasmic eosinophilic inclusions named Lewy bodies, in which α-synuclein is the major constituent. Several studies implicate abnormal protein accumulation, protein phosphorylation, mitochondrial dysfu...
Hypericum perforatum phenolic compounds : protective role in the toxicity induc...
Vieira, Pedro Miguel de SousaDissertação de mestrado em Biotecnologia e Bioempreendedorismo de Plantas Aromáticas e Medicinais ; Parkinson’s (PD) and Huntington’s (HD) diseases are neurodegenerative disorders with high prevalence. Several studies implicate abnormal protein accumulation, protein phosphorylation, mitochondrial dysfunction and oxidative stress as common pathways implicated in PD and HD pathogenesis. Polyphenolic compounds ar...
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