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In Vitro Surfactant Structure-Toxicity Relationships: Implications for Surfacta...
Inácio, Ângela S.; Mesquita, Katia A.; Baptista, Marta; Ramalho-Santos, João; Vaz, Winchil L. C.; Vieira, Otília V.Background The need for woman-controlled, cheap, safe, effective, easy-to-use and easy-to-store topical applications for prophylaxis against sexually transmitted infections (STIs) makes surfactant-containing formulations an interesting option that requires a more fundamental knowledge concerning surfactant toxicology and structure-activity relationships. Methodology/Principal Findings We report in vitro effect...
Tuberculosis: New Aspects of an Old Disease
Jordão, Luísa; Vieira, Otília V.Tuberculosis is an ancient infectious disease that remains a threat for public health around the world. Although the etiological agent as well as tuberculosis pathogenesis is well known, the molecular mechanisms underlying the host defense to the bacilli remain elusive. In this paper we focus on the innate immunity of this disease reviewing well-established and consensual mechanisms like Mycobacterium tuberculo...
Tuberculosis: new aspects of an old disease
Jordao, Luisa; Vieira, Otilia V.Tuberculosis is an ancient infectious disease that remains a threat for public health around the world. Although the etiological agent as well as tuberculosis pathogenesis is well known, the molecular mechanisms underlying the host defense to the bacilli remain elusive. In this paper we focus on the innate immunity of this disease reviewing well-established and consensual mechanisms like Mycobacterium tuberculo...
In vitro surfactant structure-toxicity relationships: implications for surfacta...
Inácio, Ângela S; Mesquita, Katia A; Jordão, Luísa; Santos, Maria S; Moreno, António J M; Vaz, Winchil L C; Vieira, Otília VSexually transmitted infections (STIs) are a major public-health problem worldwide. According to the World Health Organization there are 340 million new cases of bacterial and protozoal STIs (Gonorrhea, Syphilis, Chlamydia and Trichomoniasis) per year. The direct treatment costs and serious perinatal collateral damage caused by STIs represent hefty financial and social burdens, particularly in developing countr...
Surfactants as microbicides and contraceptive agents: a systematic in vitro study
Vieira, Otilia V.; Hartmann, Diego O.; Cardoso, Carla M. P.; Oberdoerfer, Daniel; Baptista, Marta; Santos, Manuel A. S.; Almeida, LuisBackground: The urgent need for cheap and easy-to-use protection against both unwanted pregnancies and sexually transmitted diseases has stimulated considerable interest in the use of surfactants as microbicides, anti-viral, and contraceptive agents in recent years. In the present study we report a systematic in vitro evaluation of the microbicidal, anti- viral and contraceptive potential of cationic, anionic, ...
Rapid isolation of low density lipoproteins in a concentrated fraction free fro...
Vieira, Otília V.; Laranjinha, João A.; Madeira, Vítor M.; Almeida, Leonor M.A rapid method is described for isolation and concentration of plasma low density lipoproteins (LDL) using a Beckman L80 ultracentrifuge equipped with a 70.1 Ti fixed angle rotor. The isolation of LDL achieved by a discontinuous gradient density step (180 min) was followed by a simultaneous purification and concentration step (45 min) using ultrafiltration through a collodium bag under nitrogen. This dialysis/c...
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